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Rôle des ganglions de la base dans le contrôle de la motricité : étude comportementale, électrophysiologique et neurochimique chez le rat sain et hémiparkinsonien

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dc.contributor.author Abedi Mukutenga Pamphyle, Pamphyle
dc.date.accessioned 2014-09-18T10:58:33Z
dc.date.available 2014-09-18T10:58:33Z
dc.date.issued 2013-04-08
dc.identifier.uri http://toubkal.imist.ma/handle/123456789/1285
dc.description.abstract Parkinson’s disease is a neurodegenerative disease due to basal ganglia dysfunction and characterized by the degeneration of substantia nigra pars compacta dopaminergic neurons. In this way, this thesis account for the better understanding of the basal ganglia functional organization and the pathophysiology of Parkinson’s disease. Results obtained in this work showed that the dorsomedial striatum, an associative area of the dorsal striatum, play a critical role in the striatal motor control but not in the learning ability in rat. Moreover, dopamine depletion in the globus pallidus after intrapallidal injection of 6-OHDA induced major motor deficits in rats including a decrease of locomotor activity and contralateral paw use impairment, with changes in the neuronal activity of the subthalamic nucleus and substantia nigra pars reticulata. Furthermore, intrapallidal injection of agonists and antagonists of D1 and D2 dopamine receptors induced inhibition of locomotor activity in rats, while activation of the D1 and D2 receptors caused various changes in the neuronal activity of the STN and SNr. Results of our thesis underline the key role of the globus pallidus (GP) in the control of motor function by the basal ganglia, and show that dopamine innervation of the GP plays a major role in the modulation of basal ganglia nuclei activity and that dopamine depletion in this nucleus would play a role in the pathophysiology of Parkinson’s disease. fr_FR
dc.language.iso fr fr_FR
dc.publisher Université Mohammed V - Agdal, Faculté des Sciences, Rabat fr_FR
dc.relation.ispartofseries TH-571.71 MUK;
dc.subject Biologie fr_FR
dc.subject Neurosciences fr_FR
dc.subject Maladie de Parkinson fr_FR
dc.subject Striatum dorsomédian fr_FR
dc.subject Lésion électrolytique fr_FR
dc.subject Dopamine fr_FR
dc.subject 6-hydroxydopamine fr_FR
dc.subject Globus pallidus fr_FR
dc.subject Noyau sous-thalamique fr_FR
dc.subject Substance noire pars reticulata fr_FR
dc.subject Activité locomotrice fr_FR
dc.subject Activité locomotrice fr_FR
dc.title Rôle des ganglions de la base dans le contrôle de la motricité : étude comportementale, électrophysiologique et neurochimique chez le rat sain et hémiparkinsonien fr_FR
dc.description.collaborator Lakhdar Ghazal, Nouria (Présidente)
dc.description.collaborator Errami, Mohammed (Examinateur)
dc.description.collaborator Cooper, Howard (Examinateur)
dc.description.collaborator Benazzouz, Abdelhamid (Examinateur et Directeur de la thèse)
dc.description.collaborator Benjelloun, Wail (Examinateur et Directeur de la thèse)
dc.description.laboratoire Unité Neuroscience et Cognition , (LAB.) fr_FR
dc.description.laboratoire Biologie, (Départ.) fr_FR


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